The DeOndra Dixon INCLUDE Project Act of 2025 amends the Public Health Service Act to initiate the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project. This program focuses on research and interventions for individuals with Down syndrome, including high-risk, high-reward research, clinical trials, and improving diagnosis and treatment of co-occurring conditions such as Alzheimer’s disease. The bill ensures coordination of NIH activities, prioritizes non-duplicative research, and mandates consultation with stakeholders. Additionally, it requires biennial reports to Congress detailing the research conducted or supported under the program. The bill aims to improve the quality of life and health outcomes for individuals with Down syndrome and their families.